N‐Heterocyclic Carbene Organocatalysis: With or Without Carbenes?
نویسندگان
چکیده
منابع مشابه
Organocatalysis by N-heterocyclic carbenes.
In the investigation of efficient chemical transformations, the carbon-carbon bond-forming reactions play an outstanding role. In this context, organocatalytic processes have achieved considerable attention.1 Beside their facile reaction course, selectivity, and environmental friendliness, new synthetic strategies are made possible. Particularly, the inversion of the classical reactivity (Umpol...
متن کاملSynthesis of carbenes through substitution reactions at a carbene center.
An (amino)(phosphino) carbene can be transformed into (amino)(phosphonio) carbenes, which undergo nucleophilic intermolecular as well as intramolecular substitution reactions at the carbene center. A variety of carbenes can be synthesized starting from a single carbene precursor. The resulting gamut of electronic and steric effects possible should open the way not only to a detailed study of th...
متن کاملβ-Functionalization of carboxylic anhydrides with β-alkyl substituents through carbene organocatalysis.
The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the β carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging β-alkyl substituents work effectively.
متن کاملAnterior Cruciate Ligament Reconstruction with or without Bracing
Background: Rupture of anterior cruciate ligament (ACL) would cause instability and disability and if left untreated. Reconstruction is performed by different techniques including patellar bone graft, as the strongest device. Application of brace after ACL reconstructions has revealed doubtful results. Methods: One hundred ACL ruptured patients randomized into two groups were reconstructed with...
متن کاملFunctionalization of benzylic C(sp(3))-H bonds of heteroaryl aldehydes through N-heterocyclic carbene organocatalysis.
Aryl aldehyde activation: Oxidative activation of 2-methylindole-3-carboxaldehyde (I) through N-heterocyclic carbene (NHC) organocatalysis generates heterocyclic ortho-quinodimethane (II) as a key intermediate. This intermediate then undergoes formal [4+2] cycloaddition with trifluoromethyl ketones or isatins to form polycyclic lactones containing a quaternary carbon center.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2020
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.202002656